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The biological target of FOXO4-DRI is the FOXO4p53 protein-protein interaction a molecular axis identified as pivotal for maintaining the viability of senescent cells

Pediatrics 128 (2), 344355

At first, the phrase off-label made me hesitate

Oxidative stress is related to age associated disc disease.[6] Glutathion has been shown to have a protective effect on disc cells.[7] In a recent study levels were directly related to patients with lumbar disc degeneration.[8] Serum levels of glutathione reductase, the reduced form, were significantly lower in patients with disc degeneration and disc herniation undergoing surgery compared to healthy individuals involved in the study

ARHGAP26 deficiency drives the oocyte aneuploidy and early embryonic development failure

Conclusion: We carried out an unbiased genome wide screen in human liver cell lines that identified multiple positive and negative regulators of hepatic steatosis